40Y OLD WITH SEVERE ANAEMIA

 This is an online E log book to discuss our patient's de-identified health data shared after taking his/her/guardian's signed informed consent. 


9 Feb 2022


Here we discuss our individual patient's problems through series of inputs from available global online community of experts with an aim to solve those patient's clinical problems with collective current best evidence based inputs. 

This Elog book also reflects my patient-centred online learning portfolio and your valuable inputs on the comment .


Patient and his/her attenders have been informed and their consent has been taken.

A 40 Y FEMALE WITH MULTIPLE LIFE EVENTS SINCE CHILDHOOD

HOPI

A 40yr old female who was born out of consaginous marriage grade III through a normal vaginal delivery at her mother's sister house. She immediately cried and was breast fed for 1year.

Her immunization is not known .

Since childhood she used to eat only one meal per day though she had a good appetite because of weakness, she had no energy to eat.

She used to sway side by side while walking,sometimes fell down and again she used to get up on her own.

She used to get ready to school by herself.(wearing uniform,combing hair)

She used to repeat her standard almost 2-3 times. She studied upto 10th std and gave up studies due to lack of interest.

She attained menarche at the age of 14yrs with normal flow 4-5 days/month with no clots. LMP- 5/2/2022

Once she complained of heavy bleeding for a month for which they went to local mbbs doctor who provided medications and her bleeding was relieved.

Now since 6 months ,she is having heavy bleeding per vagina during her cycles with clots for which they took medication which was prescribed earlier which was not relieved.

Then they went to local hospital where she was diagnosed as anemic and blood transfusion was suggested. But transfusion wasn't done due to unknown reasons.

Then she came to our hospital.

PEDIGREE CHART



PAST HISTORY

Not a known case of DM, Hypertension, thyroid, Asthma, TB, Epilepsy.

FAMILY HISTORY

Not significant

PERSONAL HISTORY

Diet mixed

Appetite normal

Sleep normal

Bowel and bladder movements regular

No addictions and no known allergies

GENERAL EXAMINATION

Patient is conscious,coherent and cooperative, thin built and malnourished

Pallor ++



No icterus, cyanosis, clubbing, edema, lymphadenopathy

VITALS

Temp-Afebrile

PR - 108bpm

BP-100/60 mmHg

Spo2 99%

GRBS - 87mg/dl

SYSTEMIC EXAMINATION

Frontal bossing, few hyperpigmented patches on face and crowded teeth +

Neck - diffuse goiter present

CVS

Inspection - 

JVP raised

Apical impulse diffuse in 5th and 6th IC space

Palpation - thrills and para sternal haeve +

            Apex beat in mid clavicular line

Auscultation - loud S1 S2 + at pulmonary and tricuspid area , systolic murmer +

CNS Examination

PT - c/c non Co operative

MMSE 20/30

Speech normal

Cranial Nerve examination:

CN 1 Not done

CN 2 Normal pupillary reflex

CN 3, 4, 6 Upward and lateral eye movement restricted ( She was closing eyes)

CN 5 Weak

CN 7  Weak

CN 8,9,10,11,12 Not done as she was not co operative

Sensory examination Not done as uncooperative

Motor system

Tone - Rt Lt

U/L    N N

L/L     N N


Power 

       Rt   Lt

U/L 4/5  4/5

L/L 4/5  4/5


Reflex    

Biceps 3+ 3+

Triceps 3+ 3+

Supinator 3+ 3+

Knee 3+ 3+

Ankle 3+ 3+

Plantar dorsiflexion

Sensory examination:

Pain felt

Vibration present

Joint position Present

Stereognosis present

Cerebral examination:

Gait - Swaying  to sides present but decreased

Gait

Finger nose test positive

Dysdiadokinesia positive

Romberg test


RS - BAE +

P/A - soft non tender

Now she developed Ascites


 INVESTIGATION:

HB- 1.7%

TLC - 13,100

N/L/E/M/B/- 81/06/03/10/0

PCB - 6.8%

MCV - 57.1

MCH- 14.3

MCHC-25

RDW-CV - 28

RDW - SD - 56.5

RBC - 1.19 MILLION

PLT - 74,000

BGT - O +ve

Sr.cretinine- 1.4 mg/dl

Na+ - 139

CL - 96

K- 2.9

LFT 

TB - 1mg/dl

DB - 0.2,ID - 0.8

ALT - 27, AST - 28

ALP - 114

TP - 6.9

ALB - 3.3

GLB - 3.6

Thyroid profile

T3-0.6

T4-10.72

TSH-4.16

ECG



 X ray 

Impression : Bilateral Prominent Pulmonary Arteries




USG : 
Neck - Diffuse thyroid disease with TRIADS 3 nodule in isthmus
Abdomen - No sonographical abnormalities detected

Peripheral smear : 

RBC - microcytic hypochromic with target cells, fragmented forms, pencil forms and severe anisopoikilocytosis
WBC - count increased, neutrophils show toxic granules
Impression - Microcytic hypochromic anaemia with neutrophilic leucocytosis and moderate thrombocytopenia. 
Reticulocyte count - 1.4%
LDH - 3027 IU/L

PROVISIONAL DIAGNOSIS
NUTRITIONAL DEFICIENCY to IDA or VIT B12 DEFICIENCY
 ATAXIA secondary to VIT B12 deficiency or Sub acute combined degeneration of spinal cord
HYPERDYNAMIC HEART FAILURE secondary to Severe Anaemia or PAH
Small VSD
DIFFUSE GOITRE
PDA



Rx
 1.inj TRANEXA 500MG IV stat
 2.inj pantop 40 mg iv/od
 3.inj zofer 4 mg iv/sos
 4. Plan for 1unit PRBC transfusion
 5. Monitor vitals 4th hrly
 6. I/o charting








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